In order to mitigate the rising need for in vitro diagnostics in the global COVID-19 scenario, InVivo now offers diverse SARS-CoV-2 proteins in large-scale quantities, which are suitable for the development of highly sensitive IVD kits. Using InVivo’s proprietary manufacturing platforms, different recombinant versions of the viral Spike protein have been transiently expressed in high yielding mammalian HEK cells. These include the two functional units, S1 and S2, and the Receptor Binding Domain (RBD) of the S1 subunit that directly engages with host cells via the human receptor Angiotensin Converting Enzyme 2 (ACE2). To cater to larger demand of long-term bulk quantities in the gram scale, InVivo has also initiated development of several stable CHO cell lines.
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